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Results: Immediately after erythropoietin injection, plasma erythropoietin concentration was elevated approximately 25- and 250-fold in the low and high erythropoietin dose groups, respectively.
In addition, there was no significant difference according to type of IFI (invasive aspergillosis, 50% vs. 46% in the standard and high dose groups, respectively).
Responses to these stimuli were recorded in 11%, 11%, and 14% of patients in the remifentanil 1.0, 1.5, and 2.0 μg/kg/min dose groups, respectively.
Male Sprague-Dawley rats were exposed to vanadium dissolved in drinking water at the concentration of 0.0, 0.5, 1.0 and 2.0 g/L, as the control, low-, medium-, and high- dose groups, respectively, for 12 weeks.
The 6-month actuarial progression rates were 45% versus 50% (P = 0.90) for local disease progression, and 54% versus 50% (P = 0.94) for distant metastasis for the 30 Gy and the higher dose groups, respectively.
The proportion of volunteers with moderate/severe local reactions increased significantly with increasing dosage (15%, 33% and 62% in the low, mid and high dose groups, respectively: p = 0.015), whereas dose had no significant effect on moderate/severe systemic reactogenicity (p = 0.129).
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After the 6-month follow-up period, 44 and 37 patients in the single-dose and repeated-dose groups, respectively, had completed the entire study (Table 1).
At baseline, each group was well matched for severity of VAS scores (8.26 ± 1.68 and 7.98 ± 1.60 for the single- and repeated-dose groups, respectively; Table 4).
A total of five (29.4%) individuals in the high-dose group had an AGS of 100, versus 2 (6.1%) and 20 (14.3%) in the low- and medium-dose groups respectively.
Anti-AMA-1 antibodies increased significantly in both malaria vaccine groups, peaking at nearly 5-fold and more than 6-fold higher than baseline in the half-dose and full-dose groups, respectively.
Estimated deposited brevetoxin 3 doses were 0.9 and 5.8 μg/kg/day for the low-and high-dose groups, respectively.
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