While the proposed treatment algorithm is based on the current knowledge and experience gained to date, further research will establish the best management strategy, dosing frequency and timing of injection and monitoring.
Although these changes in mRNA expression did not translate to clinically relevant differences in joint range of movement in this experiment, it does suggest that further studies investigating the route of administration, dosing, frequency, and timing are warranted.
Furthermore, questions around the optimal timing, dose, frequency, and implementation strategies are largely unanswered.
This may be due to the route of administration, dosing, frequency, and most importantly, timing.
The lack of response may reflect a fundamental defect in the proposed mechanism of action or inadequacy of exposure (dose), frequency, or timing of the investigational drug.
The doses, frequency and duration of exposure are, in fact, different in each of the cases reviewed here.
In designing future studies, we need to examine the frequency and timing of antibiotic doses required, the optimal antibiotic choice depending on the geographic variability of organisms, and possible risks.
The performed trials provide valuable information on the frequency and timing of prucalopride dosing, but it is clear that their results may need to be adapted to the needs of individual patients.
There are too few trials to determine the optimal frequency and timing of repeated praziquantel dosing.
The frequency and timing of these additional booster doses in HIV-infected children independently of ART usage still needs to be determined to improve vaccine effectiveness.
