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In specific clinical examples, we review how C10-based formulations are being tested for oral delivery of bisphosphonates using Gastro Intestinal Permeation Enhancement Technology, GIPET® (Merrion Pharmaceuticals, Ireland) and in a related solid dose format for antisense oligonucleotides (ISIS Pharmaceuticals, USA).
The most relevant section (7.3.4) of the current version (V.5.1.0) of the Cochrane Handbook (handbook.cochrane.org) does mention that reviews should provide information that is 'sufficient for replication', and gives a few examples of what this might include (eg, route of delivery, dose, format, timing).
This assay can be performed in a unit dose format with result generation in 30 minutes and is suitable for patient triage and selection for anti-endotoxin therapy.
These limitations make it difficult to perform LAL-based endotoxin assays in a single dose format suitable for rapid analysis and prospective patient selection.
The analytical attributes of the assay include a relative insensitivity to extrinsic LPS contamination, whole blood sample requirement (no need for centrifugation), rapid time to final result (approximately 30 minutes) with a relatively wide dynamic range (25 to 2,500 pg/ml WHO LPS) and a unit dose format that allows individual patient assays, obviating the need for sample batching.
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Treatment planning involves the use of different prescription dose formats and different planning techniques compared to 3D-CRT.
The first step was to design a new passive dosing format for testing DDB exactly at its saturation limit.
We had previously evaluated the use of nanosuspension to enable intravenous delivery of ten poorly soluble compounds in a cassette dosing format [34].
On the basis of these two reviews, therefore, it appears that educational interventions might have some effect on aspects of emotional status after discharge, on knowledge and medication adherence, but the results of the reviews are not straightforward and the effects seem to depend on the dose and format of the educational interventions.
Additionally, the solid/liquid ratio effect at the optimal conditions, in dose-response format, was studied in view of its upscale, not showing any significant decrease until 140 g/L.
The ThO displacement assay was used to profile the LOPAC1280 collection in a dose-response format (see PubChem BioAssay Summary, AID 1707).
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