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Dose flexibility could be achieved with various dosage forms such as oral liquids, mini-tablets, or multi-particulates.
In the short to medium term; dose flexibility, easy-to-swallow formulations, and easier access packaging are all factors under consideration.
Clinical trials in newly diagnosed patients, particularly those allowing dose flexibility, offer more useful information, but a close scrutiny of methodological details is required to avoid misinterpretation of the findings.
Superior tolerability and dose flexibility make testosterone gel highly desirable over other modalities of testosterone replacement.
In order to remove the risk, methodologies to improve the dose flexibility of single-unit dosage forms have been explored.
One potential advantage for the use of quetiapine relates to greater dose flexibility, which might be particularly helpful for very old and frail individuals.
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Study design parameters that were investigated included patient selection, definitions of adverse dropouts and serious adverse events, effective doses used, dosing flexibility (fixed versus flexible), forced titration, and titration rate.
Topiramate was titrated (25 mg weekly) to a target dose of 100 mg/day, allowing dosing flexibility from 50 to 200 mg/day, according to patient need.
This study aimed to develop taste-masked quinine tablets suitable for children and offering dosing flexibility to adjust the quinine dose in function of body weight.
Liquid formulations offer the advantage of dosing flexibility and ease of administration to young patients, but drug substances often show poor aqueous solubility.
As these and some more aspects of application affected at least two factors in the factor analysis, the characteristic "dosing flexibility" may have been defined too simple to reflect the complexity of dosing characteristics.
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