The dose fed orally to each rat was 200 mg/kg per day.
Whole blood NDGA was proportional to the dose fed male mice: 140, 55, and 25 ng mL−1 plasma at the high, middle, and low dose, respectively.
In an effort to define the toxicology and disposition of lead compounds that presently exist in paint (i.e., organic driers), a controlled dose feeding study was initiated early this year with the use of 28 infant baboons as experimental animals.
We chose the concentration of BPA to feed dams based on a previous report that this dose, fed for a similarly short period of time, produces a BPA burden (internal dose) with a mean of 10-25 ng/g tissue in brain, kidney, liver and testis, as measured by GC-MS analysis [ 12].
Animal feeding trials rarely had identical designs in food doses, feeding schedules, and routes of administration, as well as biochemical markers for antidiabetic evaluation.
But he, too, cautioned against inferring too much when it's not clear whether the doses fed to the mice truly reflect the levels at which people may be exposed.
Of note, FDA requires only bioequivalence under single-dose fed condition for the registration of venlafaxine generic drugs; thus, the situation of interchangeability for venlafaxine generic drugs in the USA can be different from Europe [ 38].
The doses fed to the mice included 20 μg LT-B, a dose protective in vaccine studies, as well as five additional doses, with each 10-fold lower than the previous one (2, 0.2, 0.02, 0.002, and 0.0002 μg LT-B).
The excretion of these compounds appears to be age dependent rather than as a result of storage capacity, as there was no difference between the groups in time to excretion or total amounts of the compounds excreted despite a 20-fold difference in the doses fed.
