Moreover, in many PSCs the HTM acts as the first line of defense to external degrading factors such as humidity, oxygen and photon dose, the extent of which depends on its hydrophobicity, permeability, and density.
Estrogens may exert a different mechanism of action depending on the timing of injection, dose, and extent of overall injury.
A strong quantitative correlation between carcinogen dose, the extent of ATPase deficient areas, and the subsequent appearance of tumors has now been established for a number of hepatocarcinogens.
In a comparison of primary pharmacokinetic parameters under fast and fed conditions (30 mg single dose), the extent of absorption was not affected significantly by food intake.
In addition to the above, we conducted extensive process evaluation to help ascertain "dose"—the extent to which intervention activities were conducted in various communities.
In the lower signal doses the extent of kinases' phosphorylation is less as compared to the higher signal doses.
The findings can be interpreted on the basis of a dosage-dependent metabolism of DTIC to an agent capable of methylation of DNA and subsequent depletion of PMC ATase: with higher DTIC doses, the extent of ATase depletion may be limited by the pharmacokinetics of DTIC metabolism.
Tanabe [ 9] and Murasugi et al. [ 10] have published articles reporting both successful and unsuccessful strategies for reducing the doses of antipsychotics, including the extent of dose reduction reported as a chlorpromazine equivalent dose, and the dose reduction period.
After 48 h incubation with TD52 at 2.5 μM or higher doses, the extents of cancer cell death, included apoptotic and necrotic death, were 50% or more in the four different HCC cells.
