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Miles et al. (2002) reported that blood and water concentrations were more closely correlated after high THM dose events such as showering.
We also had limited ability to examine the impact of episodic high THM dose events because few participants reported bathing (9%) and swimming (2%) in the 24-hr water-use diary.
This approach does introduce an artificial time structure; however, group-level analysis of person-period data permits simple univariate exploration of associations between the dose, events and selected risk factors in defined periods for signal detection purposes.
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This confounds the dose:event analysis.
First, in the drug effect compartment D the predicted AUC enters the system after each dose event.
Serum creatinine and total bilirubin concentrations are shown plotted with MTX concentrations from the last dose event.
The initial screen shows the most recent MTX dose event with the complementary monitored MTX plasma concentrations and safety markers.
Typical time courses for neutrophil count, incidences of other AEs, PSA time courses, and the fractions of the full doses received at each dose event are depicted in Figure 3. Results of the simulated scenarios are summarized in Table 3.
Laboratory and field data for interactions between western corn rootworm and Bt maize indicate that currently commercialized products are not high-dose events, which increases the risk of resistance evolution because non-recessive resistance traits may enhance survival on Bt maize.
In the present study each treatment group was exposed to a combination of one of three doses of As (0, 100, or 1000 μg As/g) and one of two types of diet, no brine shrimp (NS) or with brine shrimp (WS) for a total of eight dosing events.
Reports have been inconsistent regarding the alcohol intake threshold at which such effects occur [ 3]: some studies report that low-moderate levels of maternal alcohol consumption have no consistent significant effect on birth outcome and fetal malformation [ 4, 5], while other studies indicate even single-dose events can result in observable deficits [ 1].
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