Increased doses of AS did not impact on clinical or pharmacodynamic outcomes in this setting of emerging artemisinin resistant malaria and were toxic at the highest cumulative dose evaluated.
The results suggest that the Sa-FRF and Sb-FRF display gastroprotective activity at the dose evaluated.
The researchers found that ProCervix formulated with adjuvant shows good safety and local tolerance at the highest dose evaluated.
The difference in endometrial thickening was clinically and statistically significant in volunteers who received the 250 mg dose of fulvestrant, the dose evaluated in the breast cancer setting.
The dose evaluated for this study was selected on the basis of a dose-escalating study using SPECT, as well as tolerability data from pharmacokinetic studies.
Rapamycin increased lifespan more in females than in males at each dose evaluated, perhaps reflecting sexual dimorphism in blood levels of this drug.
There was no significant difference in body weights and side effects between the vehicle and dovitinib-treated animals at the dose evaluated (Supplementary Figure S3).
Assignation to high dose groups (70 mg/m2 and 90 mg/m) occurred after evaluation of toxicity at inferior doses, evaluated according to National Cancer Institute criteria.
AL-16049 also produced no signs of ocular irritation or discomfort in the cat at the doses evaluated.
