Suggestions(2)
Exact(12)
There were no treatment related change in mean body weight, organ/body weight ratio, histological, hematological and biochemical parameters studied in rats of either sex administered with extract at any dose evaluated.
Increased doses of AS did not impact on clinical or pharmacodynamic outcomes in this setting of emerging artemisinin resistant malaria and were toxic at the highest cumulative dose evaluated.
The results suggest that the Sa-FRF and Sb-FRF display gastroprotective activity at the dose evaluated.
The researchers found that ProCervix formulated with adjuvant shows good safety and local tolerance at the highest dose evaluated.
The difference in endometrial thickening was clinically and statistically significant in volunteers who received the 250 mg dose of fulvestrant, the dose evaluated in the breast cancer setting.
Rapamycin increased lifespan more in females than in males at each dose evaluated, perhaps reflecting sexual dimorphism in blood levels of this drug.
Similar(48)
Many dose investigation studies (40/97) were dose evaluating in nature rather than dose finding.
Twelve (of 40) of the fixed dose evaluating trials planned an interim analysis for dose confirmation, reflecting a degree of caution about dose.
Assignation to high dose groups (70 mg/m2 and 90 mg/m) occurred after evaluation of toxicity at inferior doses, evaluated according to National Cancer Institute criteria.
AL-16049 also produced no signs of ocular irritation or discomfort in the cat at the doses evaluated.
Based on these studies, the doses evaluated spanned the no observable adverse effect level, the lowest observable adverse effect level and the maximum tolerated dose.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com