Recent studies provide ample evidence on dosing errors in pediatric emergency settings with concomitant large percentage of adverse events (AE) [1 4].
Firstly, we found a significant reduction in dosing errors in the C-U, whereas Shulman and colleagues found a higher proportion of dosing errors in the CPOE group.
However, it is considered one of the medicines most commonly responsible for dosing errors in childhood by the Royal College Paediatrics and Child Health [ 18].
In the PB-U, 91% of these serious MPEs were due to dosing errors, which is significantly higher than the proportion of dosing errors in the C-U (41%, P < 0.001).
This finding indicates the need for providing doctors with information and guidelines for dose adjustment in patients with renal impairment to prevent poor clinical outcome and toxicity resulting from dosing errors in patients with renal impairment.
Fifth, we only studied the entry of a drug name, not the dose, even though designing of the interface can have a significant impact on the drug dosing errors in a health information system [ 8, 9].
The combined approach could achieve superior performance in determining the anatomical location of therapeutic dose errors and in assessing the deviation of volumetric dose parameters, thus greatly improving the clinical applicability and effectiveness of quality control during radiotherapy.
Withdrawal from the trial after enrollment only occurred because of the presence of a complicating major health problem that was not attributable to trial medication, or because of a dosing error in one dog.
In a pilot investigation assessing the quality of drug switching we evaluated 128 switches in 30 consecutively admitted patients and learnt that one in five drug substitutions (21%) was wrong, mainly due to dose errors or mistakes in switching combination drugs to multiple single agents.
The relevance of the colon dose and possible alternatives, as well as the dose errors, is discussed in the next section.
