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The dose-response curve showed a slight but non-significant shift to the left in the combined treatment group (dose effect factor (DEF) = 1.18).
ADM administered from 24 h before to 48 h after irradiation resulted in an almost constant enhancement of the radiation response, the dose effect factor (DEF) being 1.19.
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This effect modification is conceptually similar to the "dose rate effective factor" used in radiation epidemiology that describes for a specific type of radiation the effects on disease risk of total radiation dose delivered at lower (protracted or highly fractionated) dose rates compared with the effects at higher (or acute) dose rates (National Research Council 2006).
The ERR is described as, where is a dose response and describes how the response at a given dose depends on factors other than dose (effect modification).
Assuming a linear dose response function for each disease endpoint and intake route, the ecotoxicity effect factor was calculated as 0.5/ED50, where ED50 is the lifetime daily dose resulting in a probability of effect of 0.5.
The results also showed a dose effect.
Moreover, there was no dose effect.
There was a significant dose effect.
No dose effect was observed.
This illustrates the importance of considering the dose effects of environmental and genetic factors in gene environment interaction studies.
Risk factors were dichotomized, which ignores dose effects.
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CEO of Professional Science Editing for Scientists @ prosciediting.com