Sentence examples for dose effect curve from inspiring English sources

For fluids, the Frank Starling relationship between cardiac output and cardiac preload is the equivalent of the dose effect curve for standard medications.

A dose effect curve shows that doxorubicin induces changes in p16INK4A expression levels that parallel changes in the percentage of Sa-b-gal positive cells.

Following 2 days of thiocoraline treatment, the dose effect curve was plotted to determine the IC50 value using CompuSyn 1.0 Software (ComboSyn Inc., Paramus, NJ).

It is possible to measure only one concentration (50% peak serum concentration), while in the cell viability assay one has to determine a dose effect curve with four parallel samples per concentration [ 21].

Of note, this method requires that a dose effect curve for each drug is made, in which the data-points give a good r-value (>0.90 for cell systems) [ 27].

The fit of the dose – effect curves was calculated using the linear quadratic model (log  S=−α D− βD).

Chronic morphine administration (5 days, 100 mg/kg, twice daily) resulted in a 2.8-fold rightward shift in the morphine dose-effect curve.

A dose-effect curve for morphine-induced CPP (0.01 10 mg/kg, i.p). was obtained using 4-day conditioning sessions followed by a CPP test; the retention of morphine CPP was measured with CPP tests after the development of CPP.

Daily treatment with 0.56 mg/kg/day indatraline + 0.18 mg/kg/day buprenorphine produced a significant downward shift in the speedball dose-effect curve (p <.01) and transient changes in food-maintained responding.

The relative potency of each drug alone was quantified using a defined level of effect (one-quarter log shift in the morphine dose-effect curve), resulting in equieffective doses of 0.42 mg/kg and 1.1 mg/kg for CP-55940 and LY235959, respectively.

Figure 2 Dose-effect curve of propofol solitary and after pretreatment with remifentanil on guineapig's small bowel motility.