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The LD50 (lethal dose) and ED50 (optimum/effective dose) doses were determined for the active compounds in mice models infected with Mycobacterium H37Rv via ethical permission no., NCFT/EC/16/2313 assigned to Collaborative Research Group CRGG), NCFT, New Delhi, India.
The reduced doses used were 25%% less than the randomized dose (doses were 50 μg/kg/d and 25 μg/kg/d for the high and low dose groups, respectively).
Similar(58)
Patients were randomized sequentially into each dose cohort, where each patient would receive one of three active ascending CK-1827452 doses with a placebo infusion randomly interspersed in the sequence of doses; doses were separated by at least a week.
CT doses were derived from dose reports stored on the system for each acquisition.
Drug dosing: Three doses were used for each tested substance.
The pharmacokinetics of single doses were dose proportional.
Once a dose was reduced, doses were not increased in subsequent cycles.
Quinine tablets and syrup doses were all wrongly dosed.
MK-0457 demonstratedemonstratedficacy and only at higher, intolerable doses; lower doses were tolerated and no unexpected toxicities were observed.
In addition to loading doses, first maintenance doses were assessed as part of vancomycin initiation regimens.
Data regarding daily fraction radiation doses and total doses were also collected.
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