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We characterised the global genomic response following 10 cGy (low dose) and 100 cGy (high dose) doses of X-ray ionising radiation at four time points by analysing the topology of gene coexpression networks.
The LD50 (lethal dose) and ED50 (optimum/effective dose) doses were determined for the active compounds in mice models infected with Mycobacterium H37Rv via ethical permission no., NCFT/EC/16/2313 assigned to Collaborative Research Group CRGG), NCFT, New Delhi, India.
The reduced doses used were 25%% less than the randomized dose (doses were 50 μg/kg/d and 25 μg/kg/d for the high and low dose groups, respectively).
The period during which the maximal CRS-R score was maintained appeared to be longer for the second dose of the day (doses two and four) than the corresponding first dose (doses one and three).
For instance, data are not available regarding several important elements that could potentially affect the risk of complications, including RT dose, doses delivered to bladder and rectum, the use of image guided radiation therapy (IGRT), and other technical details.
The RTX dosing has varied greatly in various reports including a single dose, doses of 500 or 1000 mg given at one or two time-points and 375 mg/m once weekly for 4 weeks.
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Cows that received the highest dose (Dose 4, n = 7) all showed estrus, whereas those that received the two lowest doses (Dose 0, n = 5; Dose 1, n = 6) did not.
LET spectra and radiation quantities (fluence, absorbed dose, dose equivalent and quality factor) were measured for the space mission with different dosimeters.
Radiation quantities (fluence, absorbed dose, dose equivalent and quality factor) were measured with passive dosimeters composed of TLDs/OSLDs and CR-39 PNTDs for the STS-114 mission.
Factors potentially impacting this variability include: the choice of dose, dosing duration, assay sensitivity, statistical methodology, study population, and compliance.
In the low density tanks, the high dose (Dose 3) caused the highest percent mortality, followed by Dose 2, then Dose 1, and the control (Figure 1A).
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