Our aim is to improve accuracy and to enable individualized treatment planning and dose documentation to be performed for IORT-HDRB using a flab technique.
While some aspects of the primary care diagnosis and management of PMR, such as initial corticosteroid dose, documentation of typical symptoms, and response to steroids, appear to be in line with national guidance, documentation of other areas of care, for example a thorough process of exclusion of other diagnoses, could be improved.
These could be addressed by split dose preparation, documentation by landmarks, measurement of adenoma detection rates, measurement of serrated lesion detection rates, and education on detection of proximal colon serrated lesions.
Most important, pharmacy claims data provided only medication name and dosage form thorough medication documentation should include dose, route, and frequency.
Together, these sources will allow documentation of dose reductions of anticancer therapies, as well as the number of doses delivered.
Adjuvant or neoadjuvant chemotherapy containing an anthracycline and/or a taxane was allowed if ⩾6 months had elapsed between the last dose of chemotherapy and documentation of relapse.
From a regulatory perspective, experience with translational M&S, e.g., extrapolation of in silico drug drug interaction data to the actual clinical situation seems promising; however, current regulatory experience leading to dose advice on Data Documentation Initiatives is limited (Table 1, CS5).
For a subset of individuals, electrocardiograms were available at two escalating doses (for example, after documentation of citalopram 20 mg and of citalopram 40 mg), enabling an analysis similar to a traditional crossover design.
Of those who received 2 doses, 51% from Petite Anse and 70% from Cerca Carvajal had card documentation of both doses.
Clear documentation of date, dose and type of formulation used should be noted.
This article provides the first extensive documentation of the dose response features of pre- and postconditioning.
