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For the MCF-7 cells, the dependence on dose did not differ between the two experimental conditions (P=0.76), and the overall difference was not statistically significant (P=0.35).
For CYP2B6 A785G, though the methadone dose did not differ significantly (P = 0.42), the R,S-methadone plasma concentration was significantly different among the allele groups (P = 0.03); in particular, that of G/G carriers (5.84 ± 0.77 ng·kg/mL·mg) was higher than that of A/A carriers (5.35 ± 0.81 ng·kg/mL·mg).
During the period before the matching "heavy drinking" criteria were met, alcohol dose did not differ between groups.
Overdose rates among those who took at least one dose did not differ between the two treatment groups, and most occurred well after the last dose of medication.
There were also some secondary measures for which the higher dose did not differ from a placebo in a statistically significant way in the second trial, like the assessment of doctors as to how their patients were faring.
The rearing activity induced by 8-OH-DPAT was attenuated only at a higher dose of galanin within the first 40 min (maximal value F2,21 = 9.374 at 10 min), whereas the lower dose did not differ from the effect of 8-OH-DPAT alone.
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Average Ambulatory Measures of Sound Pressure Level, Fundamental Frequency, and Vocal Dose Do Not Differ Between Adult Females With Phonotraumatic Lesions and Matched Control Subjects.
The domains associated with lead dose do not differ in general by lead biomarker (blood, tibia, patella).
Interestingly, the glycemic control achieved with two different meal-priming insulin doses did not differ; the control algorithm appeared to compensate fully for the smaller meal-priming bolus with more reactive dosing of insulin.
Radiation absorbed doses did not differ among the three dose levels, but were lower than filtered [99mTc]sulfur colloid.
The response rates with the higher doses did not differ significantly among each other.
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