However, pretreatment with PTE increased the Δψм by the increase in ratio (in arbitrary units) of red/green fluorescent in a dose-dependent manner where it is significantly higher at 250 and 125 μg/ml (0.91 and 0.82, respectively) as opposed to 0.46 in H2O2 treated cells.
The results showed that these compounds can inhibit ROS generation during the metabolic phase of phagocytosis in a dose-dependent manner where compounds 5d and 5e were the most potent samples with higher inhibitory activities (IC50 values 3.3 and 1.4 μM, respectively) than that of the reference acetylsalicylic acid (IC50 = 9.7 μM).
Treatment of UMSCC1 or 1483 cells with the small molecule MEK inhibitor selumetinib [49] reduced EGF-stimulated cortactin S405/418 phosphorylation in a dose-dependent manner, where near elimination of phosphorylation at both serine residues occurred at doses ≥1 micromolar (Figure 2B).
Helenalin reduced clonogenicity of A2780 cells in a dose-dependent manner, where 2uM of helenalin completely suppressed clonogenic growth.
Increasing the concentration of the peptide progressively blocked cell adhesion in dose-dependent manner, where the IC50 was determined to be 33 μM as shown in Figure 4D.
Ngn3 induced formation of ectopic primary neurons in a dose-dependent manner, where 25 pg micro-injected mRNA produced substantially more extensive neurogenesis than 5 pg.
However, as the concentration of DS-SILY20 increased in IFN-γ-stimulated cultures, SMC migration was still inhibited in a dose-dependent manner, where cultures treated with 0.1, 1, and 10 μM DS-SILY20 displayed a significant reduction in migration compared to both no treatment controls and proliferative cultures treated with IFN-γ alone.
Over-expressing p53 in larval stages, on the other hand, is sufficient to extend adult lifespan in both sexes, but in a dose-dependent manner, where strong expression is deleterious for lifespan, while moderate to weak over-expression increases lifespan [ 12].
The forelimb defects thus also represent an example where Esrp2 can partially compensate for Esrp1 ablation, and that Esrp2 can modify the phenotype in a dose dependent manner.
