Whether effects of LPS on mitochondrial respiration are time and/or dose dependent is unknown.
A definite conclusion whether MSF excretion in urine was dose dependent was not possible.
Moreover, the role of Fyn is gene-dose dependent, being reduced in heterozygous neurons [ 2].
As shown in Figure 1A, the effect of DETC upon parasite load was dose-dependent, being effective at 0.5 mM and 1 mM (IC 50) and optimal at 2 mM (no surviving parasites detected) (One-way ANOVA, ***p = 0.0001; post test for linear trend, ***p<0.001) (Fig. 1A).
This effect is dose-dependent, being observed at 300 – 500 μM DCA but not at lower concentrations.
AXIN2 stabilization was dose-dependent, being in U2OS cells effective across the range from 1 to 10 μmol/L JW74 (Fig. 1C, confirmed by quantification).
The improvement was dose-dependent, being 32.0±74.3 s, 44.1±80.1 s, and 46.2±78.2 s for ivabradine 2.5 mg twice daily, 5 mg twice daily, and 10 mg twice daily, respectively, at trough drug activity.
The neuronal loss and mortality in these studies proved to be dose-dependent, being absent with 500 minimum lethal doses and mortality being higher and earlier with 2000 minimum lethal doses (Bagetta et al., 1990).
This effect of TGF-β1 was dose-dependent, being maximal at 1 ng/ml, and was prevented by the addition of an anti-TGF-β blocking antibody (Fig 5B and Supporting Information Fig S8).
