Exact(54)
Increased dose density is achieved by reducing the interval between each dose of chemotherapy.
The direct product of dose, density, and volume forms a quantity called integral dose.
The Norton-Simon model suggests that increasing the dose density of chemotherapy will increase efficacy by minimizing the opportunity for regrowth of tumor cells between cycles of chemotherapy.
The mathematical concepts and previous clinical trials of dose density that contributed to the design of CALGB 9741 will be reviewed.
A simple model of dose density distribution is developed and compared with the measured results to account for dependence of line widths on dose, focus and astigmatism.
In a 2 × 2 design, this study asked if – holding dose level and dose density constant – how simultaneous combination chemotherapy compared with purely sequential treatment, and – holding dose-level and combination or sequential use constant – how dose-density influenced disease-free and overall survival in the post-operative adjuvant setting for node-positive disease.
Similar(6)
Increased dose-density of bleomycin has been explored in the development of CBOP/BEP.
It also allows patients to be treated with the appropriate dose-density.
The overall relative dose-density for all 16 patients was mean 1.38 (range 0.72 1.5; median 1.46).
The planned elapsed time was therefore 8 weeks rather than 12 weeks for a planned relative dose-density of 1.5 for each drug compared with standard BEP.
We set no study target and a patient who completed the accelerated regimen within the planned time and received all planned doses had a dose-density of 1.5.
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