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Molecular imaging continues to impact diagnosis and staging of lung cancer, but refinements in target volume definition and eventually prescribed dose definition are needed.
Peterchev, AV; Wagner, TA; Miranda, PC; Nitsche, MA; Paulus, W Lisanbyy, SH; Pascual-Leone, A; Bikson, M, Fundamentals of transcranial electric and magnetic stimulation dose: definition, selection, and reporting practices., Brain Stimul, vol 5 no. 4 (2012), pp. 435-453 [abs1016/j.brs.2011.10.001] [abs].
Twenty-seven pareevaluableevaluable for cyclophosphamide dose definition.
Three patients had to be excluded from evaluation for dose definition because of major protocol deviations.
Instead of the maximum tolerated dose, definition of the optimum biological dose became a central theme in phase I studies (Gelmon et al, 1999; Korn et al, 2001).
If any risk structure is located ≤2 cm to a T1-enhancing lesion in pre-operative MRIs, intraoperative imaging (e.g. intraoperative ultrasound or in-room CT/MRI) should be used after removal of the tumor (to account for potential brain shifts) to document distances to the applicator surface and to allow dose definition.
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Sensitivity analyses suggest that the finding of a nonlinear MLE dose-response curve at low doses is robust to changes in internal dose definitions and more consistent with epidemiological data than earlier risk models.
For the other counties, and before 1992, county specific data on sales of hormone treatment had to be collected from paper lists and adjusted according to newer Anatomical Therapeutic Classification and defined daily dose definitions.
Monthly antibiotic use data were obtained from the hospital pharmacy and were expressed as WHO-ATC defined daily doses (DDD) and dose definitions adapted to local guidelines to account for discrepancies between DDD for penicillins and commonly and locally recommended daily doses in hospital practice (recommended daily doses [RDD]) normalized per 100 patient (occupied bed) days.
Though various protocols of level Ib delineation and dose definitions for IMRT have been reported at different treatment centers over the years [ 1, 11, 16– 21, 30], there is little evidence to address the association between elective irradiation and disease control at level Ib.
We did not specifically follow a mega-dose definition for classifying nutritional therapies as CAM or conventional medicine.
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