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All these aspects would impede the use of the model as a dose decision tool.
Routine provision of pharmacy filled medication dose decision aids would contribute to reducing medication risks for these people following discharge.
In this paper we present a warfarin dose decision tool (available as Additional file 1) developed from a published population model for warfarin.
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Agreement of the INR measurements was further assessed in relation to dosing decision.
The overall agreement was fair to good (kappa = 0.679), and 21/118 (17.8%) INR measurements showed a difference in dosing decision.
Killelea and colleagues published a description of their pediatric dosing decision support rules for a large teaching hospital [ 34].
The electronic prescribing system currently lacks renal dosing decision support; this audit suggests a potential benefit to the integration of antibiotic prescribing guidelines.
Moreover, similar variations were observed in other PK studies [ 2, 3], and especially in children, where weight is a prime consideration in drug dosing decision [ 1].
This exemplifies that the prediction of downstream response with an upstream marker will most likely yield a greater variability, which will eventually hamper the dosing decision.
Noticeably, in the present study, 21/118 (17.8%) INR measurements showed a difference in dosing decision for the anticoagulation therapy between CoaguChek XS Plus and STA-R.
The overall agreement was fair to good (kappa = 0.679; 95% CI, 0.569 0.790), and 21/118 (17.8%) INR measurements showed a difference in dosing decision between the two instruments (Table 1).
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