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Both the radioactive effluents released and their effective dose data for the period 2001 2008 were included in these calculations, and were given equal weight in constructing the NPP PRI presented here.
Weather and broadband (295 385 nm) UV dose data for the 14-year period from 1989 to 2002 show that considerable variability is expected for exposures with duration < 1 year, but that standard deviations for UV exposure and temperature are approximately 7% of the mean at 1 year and <5% at 2 years and greater.
Repeated dose data for the primary source chemicals 1-octanol and 1-dodecanol can be read-across to untested saturated alcohols of similar chain lengths.
To estimate these doses, we undertook a comprehensive dose reconstruction that used hundreds of thousands of badge doses from electronic files from 1977 onward, thousands of badge doses from hard copy records for the period 1960 76, and literature-based dose data for the period before 1960 (Simon et al, 2006).
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Three data linking methods that are currently used in E&H fields are: Stochastic-mechanistic models for linking exposure and dose data, for example, the physiologically-based pharmacokinetic (PBPK) [ 57] and the biologically-based pharmacokinetic (BBPK) models [ 58].
It is not possible to directly compare the two analyses, because dose data for Gribbin et al (1993) study have been lost.
The NDR collects and records radiation exposure and dose data for all exposed workers in Canada from 1951 (with some records going back to 1944) ((National Dose Registry (NDR), 2007).
Additional dose data for some former workers at British Energy and Magnox Generation have also been obtained.
The dosing data for both the ARIEL and DIONE trials are presented in Table 2. Plasma concentrations of darunavir and ritonavir were assessed using a previously validated liquid chromatography-tandem mass spectrometry method with a lower limit of quantification of 5.00 ng/ml for both compounds.
The results support the notion, which is already suggested by the data evaluation presented in Figure 1B, that the use of high-dose data for identifying the proper dose metric will give rise to misleading conclusions.
To assess the possible influence of a neonatal deficit of either activating or detoxifying activity on our findings, in the "Results" we include comparative analyses of the single-dose data for apparent relative sensitivity at narrowly defined time windows contrasting day 1 after birth with later periods before and after weaning.
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