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They suggest that, in low-weight patients, this dose could be lower than that previously suggested.
Depending on patient tolerability, titration could be paused or the final dose could be lower than 15 mg.
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21 It has been suggested that when combining with rituximab, the dose of synergistic cytotoxic drugs could be lower and less toxic enough to effectively exploit this mechanism of apoptosis.
Moreover, this study shows first that Indoprocaf is superior to its single active ingredients also at analgesic doses, supporting that, when used in the clinical practice, the doses of active ingredients in Indoprocaf could be lower than those of the single active ingredients when administered independently.
The true total could be lower.
In a prospective multi-center trial, we could show that the rectum dose could be significantly lowered using this gel that established a stable gap of 7 10 mm between rectum and prostate for approximately 6 months [ 17, 18].
In case of suspected drug-related hematological toxicity, the dose of Aza could be lowered according to a pre-defined scheme.
Moreover, the dose of TNF could be lowered to 10 μg per 5 ml perfusate, which might allow the use of TNF in less leakage-free or less inert perfusion settings.
Another form of treatment optimisation, however, could be lowering the dose or stopping infliximab in patients in whom infliximab is either given in a too high dose, or in whom the drug is no longer effective.
Although the statistical significance of the difference observed between the two types of regimen is borderline (p = 0.06 Mann-Whitney U test), this result suggests that a more frequent treatment even with a lower dose could be at minima as efficient, in good agreement with the short half-life of GA in vivo, i.e. a couple of hours in the human body [23].
This study also suggests that TDM should be considered in all children on LPV/r in order to find out if a lower dose could be used.
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