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32 Indeed, dose conversion ratios of less than 1 3 (such as 1 2.5) are considered to be more appropriate now.
Due to the deficiency in the available data, it remains unclear whether applied dose conversion ratios were comparable between the cited studies.
The strategies that were investigated were 1) single epoetin alfa to-peginesatide dose conversion ralfa to-peginesatideconversion tables; andose whether or not an ESA-free interval was used.
The purpose of this study was to evaluate the use of dose conversion ratios and tiered dose conversion with and without an ESA-free period as dosing strategies for peginesatide.
Although median peginesatide doses also tended to increase in those cohorts in which tiered conversion tables were used, this effect was not as pronounced as it was in those cohorts in which single dose conversion ratios were used.
This study was non-interventional and was not intended to be prescriptive of dose conversion ratios for clinical practice; nevertheless, the findings of the subgroup analyses may suggest that the conversion ratio should be <1.2, in a population clinically similar to the sample.
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18 Indeed, several consensus statements have recommended a 1 1 dose conversion ratio between incobotulinumtoxinA and onabotulinumtoxinA for aesthetic indications.
Cohorts that used tiered dose conversion tables trended towards having more stable peginesatide doses than did those cohorts that used a single dose conversion ratio.
An alternative explanation is that the initial peginesatide doses that resulted from tiered dose conversion tables were higher than those that resulted from a single dose conversion ratio.
DCR geometric mean maintenance dose conversion ratio, Hb hemoglobin When multiple assessments were available for a patient, the single assessment closest to center of the interval was used.
Nevertheless, both studies indicate that a dose conversion ratio above 1.0 is not required when switching from PEG-Epo to DA.
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