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At equivalent S-DM1 dose concentration.
97.5 % arsenic was removed at coated sand dose concentration of 5 g/100 ml.
Lower concentrations were achieved by serial dilution from the high dose concentration.
Aliquots (100 μL) of the appropriate SPA concentrations were dispensed to create eight replicates of each dose concentration.
The newly synthesized compounds were evaluated against 60 human tumor cell lines at one dose and five dose concentration levels.
The synthesized compound 1 was tested initially at a single dose concentration of 10 μM over 45 different kinases.
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Accordingly, compound 2f was screened over seven kinases at a single-dose concentration of 10 μM to profile its kinase inhibitory activity.
These compounds were evaluated for their anti-mycobacterial activity against drug sensitive Mycobacterium tuberculosis H37Rv in vitro at single-dose concentration (6.25 μg/mL).
If pre-dose concentration for an individual was >5% of Cmax, a carryover correction was made as recommended by FDA guidance (FDA, 2003).
Patients who received at least one dose of ficlatuzumab or erlotinib and had at least one measurable post-dose concentration were considered evaluable for PK analyses.
Induction of cytokines and pro-inflammatory proteins will lead to immunomodulatory effect of paclitaxel at low-dose concentration and cell death at higher dose.
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