Sentence examples for dose compensation from inspiring English sources
Here, we report the development of methods to account for local variations in defocus and beam-induced drift, and the implementation of a data-driven dose compensation scheme that significantly improves the extraction of high-resolution information recorded during exposure of the specimen to the electron beam.
Only skin samples from female donors were utilized to avoid DNA methylation differences due to dose compensation of sex chromosomes [19].
Also, if the theory of dose compensation holds true, the rank order of number of copies per species; i.e. eIF4E-1a > d > b > c, would suggest that eIF4E-1a functions as the primary translation factor.
Alternatively, wild strains may actively down-regulate expression in proportion to gene dose, known as dosage compensation.
Without dosage compensation, changes in gene dose can substantially affect gene expression, potentially resulting in detrimental effects on finely tuned gene networks (Birchler et al. 2001).
A dosage compensation mechanism, which maintains the dose of the human genome, equalizes the difference in the dose of the X chromosome between males (XY) and females (XX) via pan-chromosomal epigenetic inactivation [ 7- 9].
Full dosage compensation would undo these advantageous dose differences.
We need to understand this non-specialized response to dose in order to determine if X chromosome dosage compensation is layered over a general response or if X chromosome dosage compensation replaces a generic dosage compensation system.
The consequences of incomplete or absent dosage compensation are reduced expression of the one-dose genes [ 17, 21, 24, 26, 27] and indirect propagating effects on two-dose genes through regulatory networks [ 24, 27- 30].
In many species with heteromorphic sex chromosomes, the phenomenon of dosage compensation (DC) is apparent, wherein differences in gene dose are corrected by differences in gene expression.
Microarray-based studies in several independent male heterogametic XX/XY systems suggest that dosage compensation mechanisms are in place to mitigate the detrimental effects of gene dose differences.
