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The reasons for these false-positive signals could include inadequate surrogate markers, changes in dose, changes in usual care, changes in inclusion criteria and settings and/or the play of chance between the POP/Phase II and pivotal/Phase III RCTs.
The effect of infectious dose changes in different host genotypes.
Five studies used CDSSs to advise on maintenance prescribing, such as dose changes, in chronic therapy for drugs including statins, anti-hypertensives, and asthma medications.
Additional analyses of our results are being conducted to evaluate the impact of structured SMBG on changes in dose, changes in type of medication prescribed, and appropriateness of these changes.
Of six trials included in the previous systematic review [ 6], only two of these were eligible for inclusion in our review [ 5, 18] because of protocol-permitted sulfonylurea dose changes in the other four trials.
Although dose changes in clinical practice often occur slowly and in response to a deterioration of control from previous levels, the treat-to-target approach requires continued titration at frequent intervals until treatment targets are achieved 1, 19, 20.
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Dose, change in tumor diameters, tumor volume, and necrotic volume did not correlate with survival (p > 0.05 in all instances).
It was powered to detect a one doubling dose change in PC20 methacholine bronchial hyper-responsiveness (BHR).
Second-generation cephalosporin was prescribed for 10 days and then treatment crossover with chemotherapeutics in therapeutic dose (change in every week) during 3 months.
The composite measures incorporated several measures of asthma morbidity, including daily short-acting β-agonist dose, change in asthma controller therapy, oral corticosteroid use, and hospitalization for asthma.
If chemotherapy is not administered (mainly in case of change in dose, change in treatment, or cancellation of treatment), then good manufacturing practices require that unused doses be thrown away.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com