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But the frequent blood tests and occasional dose changes are bothersome.
Repeat ECG monitoring of QT prolongation may be indicated when significant dose changes are made withTCAs.
Firstly, it is possible that not all changes in medication (discontinuation, dose changes) are written down in medical records.
According to these data, the authors concluded that anidulafungin presents only mild pharmacokinetic changes in septic shock patients undergoing CVVHF and no dose changes are needed.
Dose changes are one of the leading causes of Hb variability, a phenomenon which is associated with increased morbidity and mortality.
This is consistent with clinical observation in epilepsy patients that dose changes are needed in the first trimester even though there are small to no weight changes at this time in the pregnancy.
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Maximum insulin doses and dose changes were limited for safety.
The median length of time of citrate infusion between dose changes was 32 hours (interquartile range 7.0 - 52.2 hours), with the longest period 112.7 hours.
The median length of time of calcium infusion between dose changes was 6.3 hours (interquartile range 2.0 - 20.0 hours) with the longest period 96.5 hours (Figure 1). Figure 1 Box Whisker Plot to show hours between dose changes of citrate (1) and calcium (2).
Dose changes were not permitted.
No dose changes were made for gefitinib.
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