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The dose calibration factor (Fcal) was determined as the ratio of the absorbed dose measured by the ionization chamber (D) at the buildup depth and the reading of the surface diode (R) under reference conditions: F cal = D R. Open image in new window (1).
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Values consistently lower than the true activity concentration were a maximum of 2.5% and are likely to originate from the calibration factor between the dose calibrator and PET scanner, although this value is well within the locally set tolerance of 5%.
All instruments were calibrated and maintained in accordance with previously reported routine quality-control procedures.[49] Activity measurements were made by using a Capintec CRC-15R Dose Calibrator (Capintec, Ramsey, NJ) with a calibration factor of 465 for 89Zr.
By using the same dose calibrator to measure the sources for computing the calibration factor and for the validation experiments, the system error, or bias, of the dose calibrator cancels out in the final results of relative errors.
Table 3 Clinically representative 177Lu MRT absorbed dose calculation using calibration factors from 3D printed organ inserts and spherical and cylindrical inserts Organ factor Sphere factor a Cylinder factor b A cumulative Abs.
However, accurate calibration of the dose calibrator is essential to obtain the exact calibration factor and absolute quantitative results in applications.
Activity at the time of the scan was corrected for the activity injected and the calibration factor of the microPET and dose calibrator (CRC 25R; Capintec Inc., Ramsey, NJ).
The representative absorbed dose calculations for 177Lu shown in Table 3 demonstrate a significant variation in calculated dose to all organs with changing calibration factor.
Activity at the time of the scan was corrected for the injected activity and the calibration factor of the micro-PET and dose calibrator.
The counting rates in the reconstructed images were converted to percent of injected dose per weight (%ID/g) by use of a system calibration factor derived from the imaging of a mouse-sized water-equivalent phantom containing 18F.
In the dose calculation process, the target dose was deduced from the diode reading with the application of a proper calibration factor (Fcal) which is corrected with OAWCF d [4].
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