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The goal of this study was to project separation between the treatment and control arms of these studies for measures of dialysis dose by using simulations based on 2-compartment variable-volume models.
The combined data will allow correlating the expression patterns of genes that are involved in biochemical and cellular responses to the irradiation dose by using the ex-vivo LINAC approach reported in this paper.
Further increasing the light dose by using longer light pulses (200 ms, 8.4 mW) did not lead to a stronger reduction of peak currents (75.3±4.0% reduction after 8 stimulations (n = 5), compared to 73.7±3.6% with 50 ms pulses), suggesting that photocurrent reduction was not a light dose-dependent phenomenon such as the bleaching of fluorophores.
Animal studies are important in confirming the predictive value of the lethal thermal dose by using histology as the reference.
We accounted for variation due to inoculation dose by using the spore counts on the sticky slides (see experimental procedures) as a covariate.
Dose banding is a recently suggested dosing method that uses predefined ranges (bands) of body surface area (BSA) to calculate each patient's dose by using a single BSA-value per band.
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However, based on our observation of no marginal and regional failures, and on > 90% local control rates achieved in stereotactic body RT studies [ 43- 45], testing concurrent gemcitabine and escalated RT doses by using "dose-painting" RT, after mapping involving site metabolic activity, may be useful.
For infant safety, it is important to ensure accuracy of calculated doses by using reliable weight measurements.
Judson et al. (2011) elaborated a framework for establishing biological pathway altering doses by using pharmaco-dynamic in vitro data together with pharmacokinetic modelling data.
Until well-founded criteria emerge, effect sizes may have to be defined arbitrarily (e.g., as 5% or 10% effect levels), as is common practice in the estimation of effect doses by using regression-based methods.
Since hematological and other toxicities have been reported when effective anti-tumour doses of gemcitabine were tested [ 10], the aim of this study was to verify the possibility of maintaining the drug cytotoxicity at lower doses, by using a liposomal drug delivery system.
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