The base case scenario assumed that 94% of children received three RV5 doses, 3% received two doses, and the remaining 3% received one dose, based on the immunization coverage levels of diphtheria, tetanus, and pertussis (DTaP), which are administered on the same schedule [ 24].
This explanation is supported by the good correlation that was found between the MRI-based mean liver absorbed dose and the absorbed dose based on the more conventional method of image-based dosimetry, SPECT.
Some say that their usefulness has not been proven and that it is not always clear how much to raise or lower a dose based on the test results.
We chose our dose based on the dose/response study by Milgrom et al. [21].
Several nuclear medicine centers determine the therapeutic absorbed dose based on the area under the pre-therapeutic time-activity curve [5 7].
Therapeutic drug monitoring (TDM) is the process of obtaining the serum concentration of a medication and modifying the dose based on the results.
A dry-capillary tube reagent-based centrifuge blood cell counter (QBC Autoread Plus, Beckon Dickinson Bioscience) measures peripheral blood lymphocytes and monocytes, which could determine radiation dose based on the kinetics of blood cell depletion.
The automatic exposure control ("CARE Dose" package by Siemens) was used in all exams to acquire CT scans according to the lowest possible patient dose, based on the reference tube current-time product (reference mAs) defined by the user.
Also, simulated optimal dose based on the ex vivo PK/PD approach was 2.9 mg/kg/day (bactericidal) to 4.3 mg/kg/day (eradication) PO against E. coli (MIC = 0.125 μg/ml).
To induce intestinal inflammation, the fish were challenged with A. hydrophila via anal intubation at 2.7 × 106 cfu/fish, an appropriate dose based on the disease activity index for inflammatory signs.
