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Forty-seven different chemotherapy regimens were administered, 16.7% with concomitant radiotherapy; 76.9% (83) had full dose at the outset.
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If the investigators hold strong prior beliefs about the magnitudes of dose and the dose effects, then it may be helpful to recognize at the outset that a proposed study may have little ability to shift posterior estimates of effect.
The MTD was defined at the outset of the trial as the highest dose level administered where ⩽1 out of 6 subjects has a DLT.
Samples were exposed to neutrophil elastase-containing buffer solutions at the outset of the experiment, and no repeat dosing was performed.
This approach was taken because it was realized at the outset that this sort of breadth and homogeneity (of low-dose evidence) does not yet exist in the literature.
Using a dose of 2uM helenalin, it was observed that levels of cleaved caspase 3, 9 and PARP were detected at the outset of 8 h post treatment with subsequent increase in cleavage with protracted treatment times.
As pointed out during peer review, we should consider at the outset whether the data is sufficient for fitting a non-linear model based on mean dose.
The deal was criticized at the outset.
But contradictions appeared at the outset.
At the outset there is excitement.
He admitted as much at the outset.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com