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Since subjects were provided with multiple canisters of DFN-02 and could repeat the dose as needed to control their symptoms, the high proportion of attacks treated with a single dose suggests that DFN-02, which contains only 10 mg sumatriptan, provided most subjects with adequate migraine relief.
All patients were given rescue medication of terbutaline 0.25 mg per dose as needed.
This observation contradicted the anecdotal assumption that the effective dose as needed is a percentage of the opioid daily dose.
For example, they will first start the patient on a low dose of a diuretic, and gradually increase the dose as needed.
Because methadone providers manage methadone dose in these patients, it is important for HIV providers to let methadone treatment providers know when a new ARV with inducing properties is initiated, so that they can monitor for opioid withdrawal symptoms and then adjust the methadone dose as needed.
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Our study subjects likely represent a highly motivated subgroup of families with type 1 diabetes who are more likely to closely monitor their children's blood glucose and give additional correction doses as needed.
For both protocols, it is important to evaluate patients clinically and to perform spirometry before each dose and as needed.
Tetracyclines may potentiate the effect of oral anticoagulants, therefore patients on oral anticoagulants should have prothrombin times monitored closely and dose adjusted as needed.
To keep the Comfort scale score between 17 and 26, the lorazepam dose was adjusted as needed to a maximum of 0.6 mg/kg in six divided doses.
For the subjects who did not achieve a remission of panic symptoms, the dose was increased as needed.
Emergency doses are replenished as needed.
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