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Total radiation dose, dose area product, number of acquisition exposures, fluoroscopy time, and complications were compared between the groups.
Dose area product (DAP) correlates well with the total energy imparted to the patient during fluoroscopic interventions.
Correlating pharmacokinetic data and toxicity, the authors found that high cumulative dose, area under the curve (AUC) for unbound platinum, and cumulative AUC were associated with ototoxicity and peripheral neuropathy.
From the dose area histograms on the film, the mean ± standard deviation of the dose covering 100% of the cross section of the target was 102.32 ± 1.20% (range, 100.59 103.49%).
p Value <0.05 was considered significant.The reduced dose cohort had a significant reduction in mean radiation dose (factory, 3650 mGy; reduced, 1650 mGy; p=0.005) and dose area product (factory, 34 700 μGy×m(2); reduced, 15 000 μGy×m(2); p=0.02).
X-Ray exposure (dose area product) ranged between 1.69 μGy m2 and 54.48 μGy m2.
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Our group already demonstrated a significant reduction of high dose areas in the PTV with VMAT plans (V107 % = 0.1 %) in comparison to 3DCRT plans (V107 % = 3.5%%) [ 7].
In this way, high dose areas may be limited to within the prostate gland itself, further reducing dose delivered to the rectum and the risk of radiation induced proctitis.
Advanced irradiation techniques such as intensity modulated radiotherapy (IMRT) [ 1], volumetric modulated arc therapy (VMAT) [ 2], and stereotactic radiation therapy (SRT) [ 3] can generate complex dose distribution with high dose areas firmly conformed to the target.
For IMRT in breast cancer treatment, a reduction in acute skin reaction in comparison to 3DCRT was demonstrated [ 35] where moist desquamation likely occurred in highest skin dose areas [ 36].
This method is superior to conventional techniques because of the reduction of high-dose area of a substantial cardiac volume in those cases where the parasternal lymph nodes are part of the target volume.
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