However, in HIC trials, highly trained mental health professionals, or the researchers themselves, have made most decisions about which components should be provided and the dose and sequencing of components.
We believe that appropriately designed clinical trials are required to define the optimum doses and sequence of treatments, and will be interesting to first try these combinations in animal models.
Some studies have demonstrated that early stage, localized nasal disease is highly curable with combination therapy, but the optimal dose, combination, and sequence of radiotherapy and chemotherapy are still undefined, and better methods of treatment are needed.
Nevertheless, it is possible that the dosing and sequencing of these combinations are crucial and that some of the doses used, with significant side effects when they are too high, may prevent the ability of any potential synergy to occur.
The addition of anti-IL-6 antibody did not affect the proliferation of cell lines exposed to radiation therapy or chemotherapy, in any of the four cell lines, regardless of the dose and the sequence of administration.
Furthermore, the DAMP spectrum can change even for the same cancer cell line depending on the type of treatment; the optimal dosing, timing and sequencing of RT, or other stimuli must be further investigated.
For this approach to be successful, it cannot jeopardise the quality of life by early acute and persistent toxicity, and feasibility still depends largely on several factors including the choice of agents, and dose and sequence (anthracyclines or taxanes first?).
However, essential questions relating to the optimisation of thoracic radiotherapy remain unanswered, including volume of irradiation, optimal total dose, fractionation, timing and sequencing of radiation.
These disparate observations in the two species suggested that the intestinal tumors in mice likely occurred via a cytotoxic MOA; however, there was insufficient information to determine the MOA due to a dearth of data describing the dose response and sequence of key events in the target tissue.
It is assumed that most genes are in a single-copy dose in a genome and sequences of duplicated genes are usually diverged to such an extent that most of their reads do not cluster together.
