Our results strengthen the association between higher phosphate doses and development of nephrocalcinosis found in earlier studies (52, 53, 54, 55).
In IHCA patients, the absence of bystander CPR, a non-shockable rhythm, high epinephrine dose and the development of shock were independently associated with ICU mortality (Additional file 1: Supplemental Tables 2, 6 and 7), but not lymphopaenia (OR 1.319 [0.708–2.458]; p = 0.38).
The aim of this study was to analyse what impact renal function has on renal absorbed dose and the development of haematological toxicity.
More detailed bone marrow dosimetry studies [ 33, 34] have shown no evident correlation between received bone marrow absorbed dose and the development of haematological toxicity.
It has been shown that an appropriate combination of chemotherapeutic drugs and gene agents can improve the therapeutic outcome and patient compliance due to reduced dose and decreased development of drug resistance 13, 14.
However, there seems to be no clear relationship between glibenclamide dose and the development of tooth discoloration within our cohort, since patient 2 was on a low dose (0.1 mg · kg−1 · day−1), and no tooth discoloration was noted in a further 62 patients with KCNJ11 diabetes who were successfully managed on similar doses of sulfonylureas.
18, 19 For example, in a retrospective comparison of 20 patients with cervical dystonia who developed antibodies and 22 who did not, a link was found between the mean dose per treatment session, total cumulative dose, and the development of neutralizing antibodies.
The adherence support approach implemented from initiation through mid-trial (months 0 15) emphasized the mechanics of gel use, understanding of dosing regimen, and development of strategies for integration of gel use into daily activity.
Therefore, further investigation of dose-response relationships and development of dosimetry methods that provide dose-volume histograms and that incorporate radiobiological modeling for the clinical practice of radioimmunotherapy are highly desirable.
Although bodyweights and feed intakes per animal were different between strains, doses and dose development curves over time are similar.
