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Intratracheal (IT) dose administration was performed using an otoscope to view vocal cords and trachea.
In our study, however, we found that the median time after dose administration was close to ideal at 11.3 hours.
One dose administration was selected as with many growth factors, there is no clear linkage between the pharmacodynamic effects of BMP-7 and its temporal presence in the blood or at the site of action.
The accumulation of TAK-285 and M-I following multiple dose administration was considered to be moderate because the mean accumulation ratios for Cmax and AUC were below 4.6 for both.
In Cycle 4, the mean trastuzumab exposure over the 24 h following dose administration was 3,094 μg*h/mL, which increased to a mean concentration of 17,322 μg*h/mL over the 3-week sampling interval.
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Recommendations for retesting and booster dose administration are variable and less well known.
Plasma pharmacokinetics and tissue distribution of KH176 and KH176m following a single intravenous (2 mg/kg) or per oral (10 mg/kg) dose administration were studied in male mice and rats.
For initial assessment of dose response, single dose administration is appropriate, however these findings should be confirmed.
Overall, mean PK parameters of apatinib after single and multiple oral dose administration are summarized in Table 2.
Primary huKS-IL2 serum PK parameters on day 2 of cycle 1 after huKS-IL2 first dose administration are summarized in Table 4 by dose cohort.
Urine samples for the PK profile after single dose administration were taken 0 4, 4 8, 8 12, 12 24, 24 36 and 36 48 h after the single dose.
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