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For initial assessment of dose response, single dose administration is appropriate, however these findings should be confirmed.
The state of the organism at the time of dose administration is an essential factor in the magnitude and direction of the effects.
BLM-induced pulmonary fibrosis with single dose administration is known to partially resolve after weeks of BLM treatment due to unknown reasons [ 30– 30].
According to the Chinese Pharmacopoeia, a study of multiple dose administration is now needed to further develop the sustained-release formulation.
Low serum levels of curcumin after single dose administration is consistent with the previously reported pharmacokinetic studies in animals and humans [ 7- 9, 17- 20].
Moreover, transudation of the orally administered NSAIDs in the synovial fluid of the patients with arthritis has been reported to be lower than that in circulation, indicating high dose administration is needed for relief pain in arthritis [ 20].
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Intratracheal (IT) dose administration was performed using an otoscope to view vocal cords and trachea.
Recommendations for retesting and booster dose administration are variable and less well known.
Overall, mean PK parameters of apatinib after single and multiple oral dose administration are summarized in Table 2.
In our study, however, we found that the median time after dose administration was close to ideal at 11.3 hours.
Primary huKS-IL2 serum PK parameters on day 2 of cycle 1 after huKS-IL2 first dose administration are summarized in Table 4 by dose cohort.
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