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Nonetheless, the average double dose adherence rate in the case control study, 74%%, was very similar to the 72 % obtained from 30-day recall of total number of sex events and empty applicator returns in the trial.
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A monthly dose of 40,000 IU/m vitamin D3 was chosen to achieve equivalent supplementation to daily dosing assuming an adherence rate of 69%, and with the goal of obtaining a serum 25(OH D concentration of 100 nmol/L [ 27, 32].
These are multiplied by 100 to attain the percentage of doses taken (missed doses would thus provide adherence rate <100% and extra doses taken would provide an adherence rate >100%).
Factors such as adherence rate, dose adjustment, length of treatment, use of concomitant medication etc. may explain the difference.
Apart from vitamin D dose and target population, adherence rate to the trial medication and achieved vitamin D concentration are often mentioned as possible sources of heterogeneity.
Of the adherence measurements, only pharmacy refill adherence was positively correlated with the virological response in a dose response relationship per each increasing adherence rate stratified category.
At HV1, baseline surveys were administered and a Doser- TM [ 28, 29] device was attached to the controller medication metered dose inhaler to measure adherence rates, or the dose-counter number was recorded on controller-delivery devices using counters (such as fluticasone diskus delivery systems).
A review of anti-hypertensive medicines found that the adherence rate for a single daily dose was significantly higher than adherence to multiple daily doses.
Overall adherence to treatment with mometasone furoate dry powder inhaler was very high in this study, with a statistically greater mean adherence rate using a once-daily dosing regimen versus a twice-daily dosing regimen.
The adherence rate (patients receiving >80% therapeutic dose of 2,403 mg/day) at 6 months was 83%.
Adherence is measured over a period of time and reported as the adherence rate, which is the percentage of dose taken in relation to what was prescribed [ 9].
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