Taken together, these findings suggest a chromosomally driven, dosage-dependent spectrum of brain morphometry.
To our knowledge, this is the first study to simultaneously investigate this set of sSCA karyotypes, not only in relation to each other and matched controls but also along a dosage-ratio spectrum and by looking at X and Y counts within sex.
In view of the ambivalent capacity of NO to act either as a proapoptotic or an antiapoptotic factor, closely related to the cell type and NO dosage, a complex spectrum of NO-mediated control of apoptosis is conceivable [ 47].
The combination of 2,4-difluorobenzyl benzimidazole derivative 5m and its hydrochloride 7 respectively with antibacterial Chloromycin, Norfloxacin or antifungal Fluconazole showed better antimicrobial efficiency with less dosage and broader antimicrobial spectrum than the separated use of them alone.
Distances of 2.5, 8, 11.5, and 14 cm were selected for treatments, in order to achieve a wide spectrum of dosages varying between 0.18 and 106.2 J/cm.
Thus, our results define a circumscribed role for diminished dosage of Tbx1 in a spectrum of phenotypes that together might account for dysphagia in 22q11DS.
Within each of these classifications, 16 different drug information categories were designed, including dosage, interactions, emerging resistance, and spectrum of activity.
The results also indicated that PGA had obviously influences on particle size distribution of ground cement, which showed a narrower grading spectrum as the PGA dosage increased.
Classifications were further divided into categories (e.g., dosage, administration, emerging resistance, synergy, and spectrum of activity).
Unlike SNPs, however, CNVs could be extremely multi-allelic (>3 segregating alleles), and may therefore contribute to continuous traits by causing a spectrum of variation in gene dosage [ 11].
