Sentence examples for dosage sensitivity from inspiring English sources

Petrovski, S. et al. The intolerance of regulatory sequence to genetic variation predicts gene dosage sensitivity.

Fehrmann, R.S. et al. Gene expression analysis identifies global gene dosage sensitivity in cancer.

Vavouri, T., Semple, J.I., Garcia-Verdugo, R. & Lehner, B. Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity.

Most congenital abnormalities resulting from mutations in T-box genes have effects in heterozygotes with more severe effects in homozygotes, indicating dosage sensitivity.

Indeed, microRNAs are known to accelerate the mRNA degradation of targeted genes and were hypothesised to play a role in increasing gene expression precision trough noise reduction (e.g. Bartel and Chen 2004; Schmiedel et al. 2015) and, in yeast, dosage sensitivity was also reported to affect gene expression noise (Lehner 2008).

What are the underlying causes of dosage sensitivity?

We henceforth use these two datasets as examples of dosage sensitivity.

Dosage sensitivity is an important evolutionary force which impacts on gene dispensability and duplicability.

These results suggest that dosage sensitivity is a significant force of negative selection on regions of copy-number variation.

This lends further support to the hypothesis that dosage sensitivity due to protein complex membership has an influence of the composition of CNV regions.

Third, we noted above that plus-end transport appears to have higher dosage sensitivity than minus-end transport to BicD levels (Fig. 3A, B).