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Head-to-head trials are comparing erythropoietic agents in a randomised setting; other trials are evaluating optimal dosage schedules.
For all species it is desirable and should be possible to design dosage schedules based on knowledge of drug pharmacokinetics and pharmacodynamics.
There have been many attempts to integrate pharmacokinetic and pharmacodynamic data to provide dosage schedules which optimize efficacy and minimize opportunities for the development of antimicrobial resistance in both laboratory animal studies and human clinical trials.
A novel means of designing antimicrobial drug dosage schedules for evaluation in clinical trials is proposed, using ex vivo AUC24 h/MIC values for bactericidal activity and elimination of bacteria together with MIC90 data for camel pathogens.
White was the first track and field athlete to be sanctioned based on evidence that did not come from a positive urine drug test, but rather from Balco information that included e-mail messages, dosage schedules and tests sent from Balco to an outside laboratory that indicated steroid use.
Additional data collected included optimum dosing and dosage schedules, adverse reactions and common side-effects, and other information intended to clarify buprenorphine's benefit risk relationship and to help prepare guidelines for its safe marketing and utilization by physicians in general clinical practice.
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Future possible developments in dosage schedule design are considered.
Azithromycin was selected as 'drug therapy of shortest dosage schedule' for common outpatient infections.
Significance: This study reiterates the effectiveness of OME treatment with an aerosolized synthetic surfactant with and without steroids and establishes a superior twice-daily dosage schedule.
The dosage schedule, already tested in younger NSCLC patients, was 60 mg/m2once a week for three weeks (first cycle), followed by 80 mg/m2 once a week until disease progression or development of unacceptable toxicity.
The Committee's notes on Celvapan said: "For Celvapan, while the CHMP awaits further data, the dosage schedule remains as two doses, with a three-week interval, in all populations". A spokesman for Baxter said: "Baxter has been granted marketing authorisation for Celvapan H1N1 pandemic vaccine and the current dosing schedule calls for two doses to be given 21 days apart.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com