Exact(4)
Further study aimed at investigating the dosage response of bFGF is needed.
This was true regardless of allele, ploidy or strain background, indicating that the dosage response of RP genes functions in laboratory-strain backgrounds.
This is in agreement with a previous study, which demonstrates the same dosage response of 10 15 μ M for other Ewing sarcoma cell lines (Merchant et al, 2002).
Dosage response of the plants was investigated after exposure to various concentrations of 5-AzaC (water control, 0.01mM, 0.10mM, 0.50mM, 1.00mM and 1.50mM) during seed imbibition by examination of a range of phenotypic traits during plant development.
Similar(56)
We observed indistinguishable dosage responses of chromosomes X and 3L in this study, suggesting that X and autosomes have similar overall responses to dosage.
If the X chromosome is inherently less or more sensitive to gene dosage reduction than autosomes, then we should observe differences between the dosage responses of chromosome X and 3L in XX females and in XX females transformed into males.
Note that while we do not focus on the expression of homoeoloci in the nullitetras here, Figure 1C shows that for BE497595, all the nullitetras except for N5BT5A show an expression pattern consistent with a dosage response to the extra copies of the 'tetra' genome.
Combining this information with our estimates of dosage response, we could identify patterns of homoeologue deployment associated with each dosage response category.
This made it possible to quantify the frequency distributions, as well as patterns of homoeologue deployment, for each kind of dosage response.
Once an estimate of transcriptome size was obtained, estimates of dosage response could then be made for each gene in the transcriptome profiling data set.
Thus, we were able to explore patterns of homoeologue deployment under each dosage response.
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