Neoallopolyploids would possess a greater number of matching alleles than their more resistant parent, but the dosage of resistance factors would be reduced compared to the resistant parent.
Izh3p dosage affects resistance to polyene drugs in yeast, similar to Izh2p (Villa et al. 2011).
Second, it can predict the relevant biological pathways, protein-protein interaction networks, and gene ontology functional groups, thus identifying novel therapeutic targets/biomarkers for drug discovery, with the hope that their variations from patient to patient could explain large portion of dosage variation, resistance and efficacy of the drug [ 11].
While he was prescribed nelfinavir, abacavir and zidovudine, it was suspected that he was not consistently taking full dosage, and genotypic resistance studies showed no evidence of significant resistance-associated mutations in the HIV PR or RT regions (not shown).
A melphalan-resistant human rhabdomyosarcoma xenograft, TE-671 MR, was established in athymic mice by serial melphalan treatment of the parent xenograft, TE-671, at the 10% lethal dosage (LD10); significant resistance was evident after ten passages of the tumor.
"Those people who do not comply with the treatment, or take drugs for an insufficiently long time or in the wrong dosage, may develop resistance to the treatment," Dr. Pieter van Maaren, the World Health Organization representative for Papua New Guinea, told VICE News.
Numerous Lx genes will increase protein or mRNA dosage, leading to resistance in plants.
Classifications were further divided into categories (e.g., dosage, administration, emerging resistance, synergy, and spectrum of activity).
Within each of these classifications, 16 different drug information categories were designed, including dosage, interactions, emerging resistance, and spectrum of activity.
