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High intravenous (iv) doses of vitamin C are required to increase plasma concentrations to normal and supra-normal ranges [2], but the optimal dosage regime in this population remains unclear.
All these pharmacokinetic data of baicalin in blood and cerebral nuclei would be useful to the dosage regime design when baicalin, Scutellariae Radix extract or the prescriptions containing Scutellariae Radix as the main ingredient are prescribed.
Seasonal IPT reduced the incidence of clinical malaria by 17 86% depending on antimalarial drug and dosage regime [5], [6].
Preserving the route of drug administration the active signal DR N) must increase in magnitude in order for the system to respond to a multitude of external signals (LPS, Drug .Therefore, dose-dependent profiles are simulated in Figure 12 and Figure 13 where there exists a dosage regime that modulates the dynamics of the system towards resolution.
Consequently, a longer pretreatment dosage regime was employed.
The regime of three tablets three times a day is a difficult dosage regime.
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An awareness of these factors is important in establishing optimal dosage regimes to treat lower airway infections in horses.
There was variation in dosage regimes, from 3x/weekly administration of intravenous iron to daily oral iron for up to 30 days post discharge.
At present, pharmacokinetic-pharmacodynamic (PK-PD) modeling has emerged as a major tool in clinical pharmacology to optimize drug use by designing rational dosage forms and dosage regimes.
However, as all compounds are not chemically stable in lipid based systems, alternative dosage regimes could be investigated to evade the stability issue.
This study supports the emerging "discrete analysis " which, in the near future, is anticipated to be a promising major tool, for designing rational dosage regimes and effective dosage forms.
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