Exact(1)
Time-sensitive actions to optimally manage DILI include discontinuation of the study drug in a timely manner, avoiding re-challenge, modification of dosage, performance of time-sensitive diagnostic tests and institution of therapeutic interventions.
Similar(59)
Thereby, the food, chemical, pharmaceutical and coating industries set high demands on the transport and dosage performances of the used plants.
Group differences in cortical thickness were assessed using statistical difference maps, and regions of cortical thinning were correlated with medication dosage and performance on neurocognitive tasks.
We examine the sometimes contradictory literature in this area and highlight specific case studies which demonstrate the effect of intestinal transit on dosage form performance and drug absorption.
Likewise, the often detrimental effects of alcohol (ethanol) on dosage form performance have been widely observed experimentally, but knowledge of which has only moderately impacted on clinical practice.
Yet it is of great importance to consider other parameters to fully resolve the interplay between microstructure and dosage form performance.
The behavior of pharmaceutical hydrates has become the object of increasing attention over the past decade, primarily due to the potential impact of hydrates on the development process and dosage form performance.
Since the microstructure can affect solid dosage form performance such as mechanical properties, a second objective was to study the influence of the type of adsorbent and of the presence of an amorphous compound on extrudate hardness.
However, commercially available FDM printers are extremely limited with regards to the materials that can be processed to few types of thermoplastic polymers, which often may not be pharmaceutically approved materials nor ideal for optimizing dosage form performance of poor soluble compounds.
This review summarizes the current knowledge on anatomy and physiology of the human gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and mouse) with emphasis on in vivo methods for testing and prediction of oral dosage form performance.
Such evidence could include admissions by athletes; documents detailing the sale and dosages of performance-enhancing drugs to specific athletes; the testimony of witnesses; e-mail messages; bank records; telephone wiretaps; and circumstantial evidence, officials in the case said.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com