They were most commonly related to information sharing; for example, procedures that described sending letters to other caregivers, or the patient, with different content, or procedures concerning a service for customized dosage packages of drugs called ApoDos [ 31].
The PRE2DUP method is based on purchase histories and uses temporal dosages, package information with refill time distributions and patient's personal purchase patterns.
Via the PZN linkage to drug information systems is possible, allowing for characterization of the product with regard to e.g. the amount and type of active ingredient, dosage form, package size etc.
We carefully noted the descriptions (ingredients, quantity, dosage form, package presentation, usage instructions, safety information, manufacture date, expiration date, batch number, name and address of the manufacturer) on the website and package insert or the summary of product characteristics of the items purchased.
When a stability study includes all combinations of dosage strength, packaging, and storage times, the stability design is referred to as a "full-factorial" design.
There is robust evidence that such simplifications, regarding, for example, dosage and packaging, improve patient adherence.
Table 2 shows that technical solutions, mainly consisting of simplifying the dosage and packaging, were effective in seven reviews.
Technical adherence interventions, for example on dosage and packaging, are usually directed at simplifying the medication regimen.
Effective adherence interventions, for example, include new solutions such as simplification of dosage and packaging (Holloway and van Dijk 2011), including combination therapies.
Progress from action to adoption was influenced by caretakers' understanding of dosage, the packaging of chlorine products, knowledge and skills for multipurpose laundry bleach, the taste of treated water, and reinforcement.
