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Dissection of this phenotype in zebrafish embryos revealed a complex genetic architecture: dosage perturbation of four genes (ASGR1, ACADVL, DVL2, and GABARAP) impeded neurodevelopment and decreased dosage of the same loci caused a reduced mitotic index in vitro.
Duplicate genes that are retained either provide an increased dosage of the same product or go through a process of subfunctionalization, during which both copies of the gene lose a subset of their ancestral functions, while acquiring new properties [7], [8], [18].
For simplicity, only forward reads were used because reverse reads contained redundant information (dosage of the same nucleosome, at the other extremity).
The second study used letters to notify physicians and patients of formulary changes and showed a small increase in conversion of inefficient dosage regimens to a recommended daily dosage of the same medication [ 55].
In conclusion, methadone administered as premedication at a dose of 0.7 mg/kg had a better effect on pain control after orthopaedic surgery compared with a lower dosage of the same drug and with tramadol.
It is also important to stress at this point, that strains harboring mutations conferring low-level resistance can often be treated effectively with existing drugs [ 77], either by increasing the dosage of the same drug, or by using alternative drugs from the same class, as is the case of FQ [ 78].
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This study sought to compare the effects of aggressive and conventional lipid lowering by two different dosages of the same statin on early human atherosclerotic lesions using serial noninvasive magnetic resonance imaging (MRI).
50 Another use is the adjustment of doses where different trials have used various dosages of the same treatment.
Comparisons of different dosages of the same intervention only, or comparison of the same interventions with different background treatments were excluded.
Collectively, these studies draw serious attention to the issue of dynamic responses of immune cells when challenged with varying dosages of the same stimulant.
We previously published a study comparing two transfusion dosages of the same RBC product in two Dutch tertiary care neonatal units (NICUs) using the same transfusion trigger protocols [ 2].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com