However, the therapeutic window for the optimal dosage of compound 6 may have a very narrow range from 15 to less than 60 mg·kg−1·daccordingrding to the infarct volume, ROS production, the activity of SOD, GPx and MDA levels.
For combination regimens, it was at the physicians discretion to reduce all or only one dosage of the compounds.
Likewise, the study of drugs also benefits from animal models, bioassays to detect the compound, the ability and ease to generate the compound, and the ability to deliver an appropriate dosage of the compound to the targets of interest.
On the other hand, co-administration of two separate compounds (such as crizotinib and axitinib) would allow flexibility when the dosage of each compound or pathway needs modification.
The correct dosage of this compound is essential to avoid under- or over-anesthesia that may result in serious side-effects.
Given the different effect of dietary forages on the pH decline of urine after anionic supplementation, the metabolic acidotic condition in close up dry cows should be monitored by the urinary pH to calibrate the dosage of anionic compound feed.
6 h after injection, mice were administrated i.p. with drug cocktails (Combination and dosage of each compound was same as the above treatment) or saline.
To ensure that genistein-treated groups received a pharmacological dosage of the compound, serum concentration of genistein was measured using high-performance liquid chromatography- mass spectrometry (HPLC-MS).
Ongoing oxidative stress resulting from inadequate dosage of the compound may account for this result [ 3].
The dosage of each compound was determined as the highest dose that did not affect seizure threshold in the preliminary study.
Combinations of two or more agents that exert a synergistic effect can overcome the undesirable toxicity and other side-effects associated with high doses of single drugs, allowing a reduced dosage of each compound.
