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When polyaluminum chloride (PACl) dosage was set as 0.025 mM (as alum), the removal efficiency of organic matter and residual turbidity were slightly inferior to 0.1 mM (as alum), but four times dosage lowered than the optimal-dosing.
Study medication was either stopped or the dosage lowered in accordance with the protocol if (serious) adverse events 14 were seen by the attending rheumatologist.
At the dosage lowered to 1/10 of a milligram per kilogram, ZB497 remained therapeutically effective in inhibiting xenograft tumor growth, whereas tamoxifen largely lost its efficacy for tumor inhibition at this dose.
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It has also given a $380,000 grant, Ms. Chesler said, to researchers studying whether a dosage lower than what regulators approved for the drug could be used.
The effect of Cr3+ on early hydration of C3S varies with its dosage, lower dosage Cr3+-doping accelerates the early hydration of C3S, whereas, higher dosage Cr3+-doping leads to the formation of new well crystalline Cr-rich phase and exhibits severe retardation effects.
At dosage lower than 100 ppm, very low inhibition rate can be observed, the inhibition rate increases with further addition of the polymer inhibitor.
In these analyses, those with a dosage higher than the median dosage had a lower hazard (0.87 [0.85–0.88]) than those starting on a dosage lower than the median dosage (0.91 [0.91–0.91]).
We further showed in this study that taxane treatment arrested the cells at M phase at the dosage lower than 1 μM, which eventually leads to cell apoptosis.
DEN dosage lower than 10 mg/kg can only initiate cancerous transformation, while 10 mg/kg DEN can lead to liver fibrosis [ 26].
Although the safety analyses included patients from both parts 1 and 2 of the study, only three patients received a dosage lower than the MTD (i.e., neratinib 160 mg per day plus paclitaxel).
Patients in both groups continued to take medication during the six-month study, though the dosages were lowered for some of those who had the surgery.
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